I definitely agree with Gameprinter regarding Pathfinder; in one of my current campaigns we just made the switch from 3.5e to "3.75e" and haven't looked back since! Also, I don't know if you are aware of the Obsidian Portal yet or not, but it's an incredible useful tool for DM's. Basically it's a site that allows you to use a wiki based system to organize all of your campaign related information. There are both free, and paid accounts. If you want to get a feel for what you can do with a free account, I'd invite you to take a look at my Tales of Darkmoon Vale campaign site. Also, while I have not found the Obsidian Portal community overall to be as actively involved in their forums as the Cartographers Guild is, there are some regular contributors and there are some great topics on game mastery worth checking out.

Cheers,
-Arsheesh