Adobe Photoshop, Inkscape, and Fractal Mapper. Photoshop for modifying images, Fractal Mapper for maps, and Inkscape for general drawing.

I do own a copy of Campaign Cartographer 3 (and CC2, actually), but I would rather stab myself in the eyes and draw with my own blood rather than use it. Fractal Mapper can do everything CC can do with one-tenth the effort.

I also own Adobe Illustrator (I have CS4), but I prefer to use Inkscape for general drawing.