There's not really any way for us to be able to answer that one for you, but I could help you to clarify it for yourself. Do you ever draw with pencil and paper? What size paper do you prefer to use? Do you find yourself drawing all the way to the edges, or do you commonly fill only a portion of the page with a single drawing?

I have observed that people who paint tend to like the larger tablets, as they are accustomed to the larger strokes. As for me, I find the smaller tablets to be surprisingly comfortable, although I still do prefer the medium-sized one I have at home.