In CC3 (I've not tried making a city with any other software yet), I generally stick to the default scale of the city symbols. That's '1' by default. That way all the buildings are in scale with each other. If the map turns out to be too small I simply make the map area bigger.
Where buildings created with the HOUSE command are concerned, I generally paste a few temporary building symbols around the place first to give me a general idea to work with as I'm creating them, then remove the temporary buildings when I'm done.
It also helps to have a grid visible, so that you can see if you are making a building that is less than 5 foot wide, or whatever.
Hope that helps