Now that I've absorbed so much detail about all the different hospitals that were built over the period when Kirkbride was still the vogue, I think it would be fairly easy to design your own detail and move things around quite a lot - yes. Even it if ends up being really quite different to the original plan, the same is true of many of the later hospitals. I really like the flying corridors that link the wards in the later buildings

It may be more important to get the flavour of the architecture right, rather than the accuracy. Convincing building materials on the outside, and period décor on the interior will probably have some visitors thinking your model is one of a real Kirkbride building no matter what shape it ends up being