If head precisely north and south from the equator, scale doesn't change on a cylindrical projection like Equirectangular, so you're good. As you start to move east and west, though, the effects of projections start to come into play. The angular shrinkage east and west compared to north/south is proportional to cos(latitude), so at 25 degrees latitude (=111km/deg*25deg=2775km, the same number of degrees east and west is 90% of the size that it would be at the equator (94% at 20 degrees=2220km, 97% at 15 degrees=1665km). For a 600 mile trip near the equator, a straight line is probably a good enough approximation.
There are a number of useful calculation that relate distances on a sphere. Ed Williams' Aviation Formulary (
http://edwilliams.org/avform.htm ) lists many common formulae that might be of use to you. From that page: The great circle distance d between two points with coordinates {lat1,lon1} and {lat2,lon2} is given by: d=acos(sin(lat1)*sin(lat2)+cos(lat1)*cos(lat2)*cos (lon1-lon2)).