What kind of city are you going for? That question has a lot of significance on how the city should look.
Modern cities in wealthy countries, like those that are common in Australia, Canada, and the United States, will tend to have different neighbourhoods with different uses (a downtown area for shops and businesses, suburbs full of residential dwellings, segregated industrial uses, etc.). As cities that were founded in a more modern era (post-Renaissance, in most cases), they will tend to have more modernistic features, such as:
--straight roads and avenues,
--wide streets (for use by motor traffic, rather than just pedestrians),
--different forms of architecture depending on use (eg. structures with very large footprints for skyscrapers; free-standing houses for suburban houses, etc.)
--a lack of narrow alleyways, courtyards and 'negative spaces' between buildings, dense clustering of structures due to poverty etc.
Contrast this with a more historic city (i.e. pre-Renaissance), such as Rome, London or Madrid. These cities grew through 'organic' processes: this means, the gradual development of a town over the course of a long period of time, in the absence of town planners (i.e. in the absence of anyone giving directions or setting rules*). The result was that these cities tended to be less segregated: i.e. different uses were in close proximity to each other; a classic example is a building with shop/s on the ground floor and residential above (and often a work-yard in the rear, too). Typical characteristics of these cities are:
--streets that are not straight (avoid 'spaghetti' style streets, though) or consistent in width,
--streets that vary in width along their length, and include alleyways as well as major highways,
--buildings which often have much more complicated shapes (eg. houses with courtyards, houses with separate annexes etc.),
*Note: these cities, and many others like them, did in fact have people who gave directions. But rarely was town planning a systematically applied craft before the modern era.
Essentially, a few things to keep in mind with street layouts:
--where did the street come from (farmers walking to the fields, merchants going to the market, goods being dropped off somewhere)?
--although cities can be divided between planned and unplanned, there is no such thing as a purely planned or purely unplanned city
--following from the above point, most cities will have a bit of both, but in varying degrees (possibly too subtle to be seen)
--this is a good example of a modern-style city (New York):
https://metrhispanic.files.wordpress.../crhysler1.jpg
--this is a good example of a historic city (Rome):
https://landlab.files.wordpress.com/...roma-17482.jpg
Hope that's vaguely helpful.
THW